2021
Bielsa, N.; Casasampere, M.; Aseeri, M.; Casas, J.; Delgado, A.; Abad, J. L.; Fabriàs, G. Discovery of Deoxyceramide Analogs as Highly Selective ACER3 Inhibitors in Live Cells. Eur. J. Med. Chem. 2021, 216, 113296.
Izquierdo, E.; Casasampere, M.; Fabriàs, G.; Abad, J. L.; Casas, J.; Delgado, A. Synthesis and Characterization of Bichromophoric 1-Deoxyceramides as FRET Probes. Org. Biomol. Chem. 2021, 19, 2456-2467
López, S.; Domínguez, A.; Guerrero, Á.; Quero, C. Inhibitory Effect of Thymol on Pheromone-Mediated Attraction in Two Pest Moth Species. Sci. Rep. 2021, 11 (1), 1223.
2020
Bartoll A, Toledano-Zaragoza A, Casas J, Guzmán M, Schuchman EH, Ledesma MD. Inhibition of fatty acid amide hydrolase prevents pathology in neurovisceral acid sphingomyelinase deficiency by rescuing defective endocannabinoid signaling. EMBO Mol Med. 2020 Nov 6;12(11):e11776. Epub 2020 Oct 5.
Belleri M, Paganini G, Coltrini D, Ronca R, Zizioli D, Corsini M, Barbieri A, Grillo E, Calza S, Bresciani R, Maiorano E, Mastropasqua MG, Annese T, Giacomini A, Ribatti D, Casas J, Levade T, Fabrias G, Presta M. β-Galactosylceramidase Promotes Melanoma Growth via Modulation of Ceramide Metabolism. Cancer Res. 2020 Nov 15;80(22):5011-5023.
Coll-Martínez, B.; Delgado, A.; Crosas, B. The Potential of Proteolytic Chimeras as Pharmacological Tools and Therapeutic Agents. Molecules 2020, 25 (24), 5956
Casasampere, M.; Izquierdo, E.; Casas, J.; Abad, J. L.; Liu, X.; Xu, R.; Mao, C.; Chang, Y.-T.; Delgado, A.; Fabrias, G. Click and Count: Specific Detection of Acid Ceramidase Activity in Live Cells. Chem. Sci. 2020, 11, 13044–13051
Maharaj, A.; Williams, J.; Bradshaw, T.; Güran, T.; Braslavsky, D.; Casas, J.; Chan, L. F.; Metherell, L. A.; Prasad, R. Sphingosine-1-Phosphate Lyase (SGPL1) Deficiency Is Associated with Mitochondrial Dysfunction. J. Steroid Biochem. Mol. Biol. 2020, 202 (November 2019), 105730
Pearson, J. M.; Tan, S.-F.; Sharma, A.; Annageldiyev, C.; Fox, T. E.; Abad, J. L.; Fabrias, G.; Desai, D.; Amin, S.; Wang, H.-G.; et al. Ceramide Analogue SACLAC Modulates Sphingolipid Levels and MCL-1 Splicing to Induce Apoptosis in Acute Myeloid Leukemia. Mol. Cancer Res. 2020, 18 (3), 352–363.
Muñoz-Guardiola, P.; Casas, J.; Megías-Roda, E.; Solé, S.; Perez-Montoyo, H.; Yeste-Velasco, M.; Erazo, T.; Diéguez-Martínez, N.; Espinosa-Gil, S.; Muñoz-Pinedo, C.; et al. The Anti-Cancer Drug ABTL0812 Induces ER Stress-Mediated Cytotoxic Autophagy by Increasing Dihydroceramide Levels in Cancer Cells. Autophagy 2020, 15548627.2020.1761651.
Pons, G.; Riba, D.; Casasampere, M.; Izquierdo, E.; Abad, J.-L.; Fabriàs, G.; Rodríguez Ortega, P. G.; López-González, J. J.; Montejo, M.; Casas, J.; et al. A Mechanism-Based Sphingosine-1-Phosphate Lyase Inhibitor. J. Org. Chem. 2020, 85 (2), 419–429.
Randez-Gil, F.; Prieto, J. A.; Rodríguez-Puchades, A.; Casas, J.; Sentandreu, V.; Estruch, F. Myriocin-Induced Adaptive Laboratory Evolution of an Industrial Strain of Saccharomyces Cerevisiae Reveals Its Potential to Remodel Lipid Composition and Heat Tolerance. Microb. Biotechnol. 2020, 13: 1066-1081
Meglič, A.; Ilić, M.; Quero, C.; Arikawa, K.; Belušič, G. Two Chiral Types of Randomly Rotated Ommatidia Are Distributed across the Retina of the Flathead Oak Borer Coraebus Undatus (Coleoptera: Buprestidae). J. Exp. Biol. 2020, 223 (14), jeb225920
2019
Casasampere, M.; Bielsa, N.; Riba, D.; Bassas, L.; Xu, R.; Mao, C.; Fabrias, G.; Abad, J.-L.; Delgado, A.; Casas, J. New Fluorogenic Probes for Neutral and Alkaline Ceramidases. J. Lipid Res. 2019, jlr.D092759.
Domínguez, A.; López, S.; Bernabé, A.; Guerrero, Á.; Quero, C. Influence of Age, Host Plant and Mating Status in Pheromone Production and New Insights on Perception Plasticity in Tuta Absoluta. Insects 2019, 10 (8), 256.
Guerrero, A.; Ramos, V. E.; López, S.; Alvarez, J. M.; Domínguez, A.; Coca-Abia, M. M.; Bosch, M. P.; Quero, C. Enantioselective Synthesis and Activity of All Diastereoisomers of ( E )-Phytal, a Pheromone Component of the Moroccan Locust, Dociostaurus Maroccanus. J. Agric. Food Chem. 2019, 67 (1), 72–80.
Solé, M.; Monge, M.; André, M.; Quero, C. A Proteomic Analysis of the Statocyst Endolymph in Common Cuttlefish (Sepia Officinalis): An Assessment of Acoustic Trauma after Exposure to Sound. Sci. Rep. 2019, 9 (1), 9340.
Ordóñez, Y. F.; Abad, J. L.; Aseeri, M.; Casas, J.; Garcia, V.; Casasampere, M.; Schuchman, E. H.; Levade, T.; Delgado, A.; Triola, G.; et al. Activity-Based Imaging of Acid Ceramidase in Living Cells. J. Am. Chem. Soc. 2019, 141 (19), 7736–7742.
Benson, S.; Fernandez, A.; Barth, N. D.; de Moliner, F.; Horrocks, M. H.; Herrington, C. S.; Abad, J. L.; Delgado, A.; Kelly, L.; Chang, Z.; et al. SCOTfluors: Small, Conjugatable, Orthogonal, and Tunable Fluorophores for In Vivo Imaging of Cell Metabolism. Angew. Chem. Int. Ed. 2019, 58 (21), 6911–6915.
Samaranch, L.; Pérez-Cañamás, A.; Soto-Huelin, B.; Sudhakar, V.; Jurado-Arjona, J.; Hadaczek, P.; Ávila, J.; Bringas, J. R.; Casas, J.; Chen, H.; et al. Adeno-Associated Viral Vector Serotype 9–Based Gene Therapy for Niemann-Pick Disease Type A. Sci. Transl. Med. 2019, 11 (506), eaat3738.
Meneses-Salas, E.; García-Melero, A.; Kanerva, K.; Blanco-Muñoz, P.; Morales-Paytuvi, F.; Bonjoch, J.; Casas, J.; Egert, A.; Beevi, S. S.; Jose, J.; et al. Annexin A6 Modulates TBC1D15/Rab7/StARD3 Axis to Control Endosomal Cholesterol Export in NPC1 Cells. Cell. Mol. Life Sci. 2019, https://doi.org/10.1007/s00018-019-03330-y.
2018
Schulte-Zweckel, J.; Schneidewind, T.; Abad, J. L.; Brockmeyer, A.; Janning, P.; Triola, G. Azide-Tagged Sphingolipids for the Proteome-Wide Identification of C16-Ceramide-Binding Proteins. Chem. Commun. 2018, 54 (97), 13742–13745.
Fanani, M. L.; Busto, J. V.; Sot, J.; Abad, J. L.; Fabrias, G.; Saiz, L.; Vilar, J. M. G.; Goni, F. M.; Maggio, B.; Alonso, A. Clearly Detectable, Kinetically Restricted Solid-Solid Phase Transition in Cis-Ceramide Monolayers. Langmuir 2018, 34 (39), 11749–11758.
Faria, M.; Fuertes, I.; Prats, E.; Abad, J. L.; Padrós, F.; Gomez-Canela, C.; Casas, J.; Estevez, J.; Vilanova, E.; Piña, B.; et al. Analysis of the Neurotoxic Effects of Neuropathic Organophosphorus Compounds in Adult Zebrafish. Sci. Rep. 2018, 8 (1), 4844.
Izquierdo, E.; Delgado, A. Click Chemistry in Sphingolipid Research. Chem. Phys. Lipids 2018, 215, 71–83.
Ordóñez-Gutiérrez, L.; Benito-Cuesta, I.; Abad, J. L.; Casas, J.; Fábrias, G.; Wandosell, F. Dihydroceramide Desaturase 1 Inhibitors Reduce Amyloid-β Levels in Primary Neurons from an Alzheimer’s Disease Transgenic Model. Pharm. Res. 2018, 35 (3), 49.
2017
Cingolani, F.; Simbari, F.; Abad, J. L.; Casasampere, M.; Fabrias, G.; Futerman, A. H.; Casas, J. J. Lipid Res. 2017, 58, 1500–1513.
Stauffert, F.; Serra-Vinardell, J.; Gómez-Grau, M.; Michelakakis, H.; Mavridou, I.; Grinberg, D.; Vilageliu, L.; Casas, J.; Bodlenner, A.; Delgado, A.; Compain, P. Stereodivergent Synthesis of Right- and Left-Handed Iminoxylitol Heterodimers and Monomers. Study of Their Impact on Beta-Glucocerebrosidase Activity. Org. Biomol. Chem. 2017, 15 (17), 3681–3705.
Sanllehí, P.; Casasampere, M.; Abad, J.-L.; Fabriàs, G.; López, O.; Bujons, J.; Casas, J.; Delgado, A. The First Fluorogenic Sensor for Sphingosine-1-Phosphate Lyase Activity in Intact Cells. Chem. Commun. 2017, 53 (39), 5441–5444.
Calderón, R.; Mercadal, N.; Abad, J.-L.; Ariza, X.; Delgado, A.; García, J.; Rodríguez, A.; Fabriàs, G. Stereoselective Preparation of Quaternary 2-Vinyl Sphingosines and Ceramides and Their Effect on the Basal Sphingolipid Metabolism. Chem Phys Lipids 2017, 205, 34–41
Gómez-Grau, M.; Albaigès, J.; Casas, J.; Auladell, C.; Dierssen, M.; Vilageliu, L.; Grinberg, D. New Murine Niemann-Pick Type C Models Bearing a Pseudoexon-Generating Mutation Recapitulate the Main Neurobehavioural and Molecular Features of the Disease. Sci. Rep. 2017, 7, 41931.
Sikora, J.; Dworski, S.; Jones, E. E.; Kamani, M. A.; Micsenyi, M. C.; Sawada, T.; Le Faouder, P.; Bertrand-Michel, J.; Dupuy, A.; Dunn, C. K.; Xuan, I. C. Y.; Casas, J.; Fabrias, G.; Hampson, D. R.; Levade, T.; Drake, R. R.; Medin, J. A.; Walkley, S. U. Acid Ceramidase Deficiency in Mice Results in a Broad Range of Central Nervous System Abnormalities. Am. J. Pathol. 2017, 187 (4), 864–883.
Pou, A.; Abad, J.-L.; Ordóñez, Y. F.; Garrido, M.; Casas, J.; Fabriàs, G.; Delgado, A. From the Configurational Preference of Dihydroceramide Desaturase-1 towards Δ6-Unsaturated Substrates to the Discovery of a New Inhibitor. Chem. Commun. 2017, 53 (31), 4394–4397.
Torres, S.; Matías, N.; Baulies, A.; Nuñez, S.; Alarcon-Vila, C.; Martinez, L.; Nuño, N.; Fernandez, A.; Caballeria, J.; Levade, T.; Gonzalez-Franquesa, A.; Garcia-Rovés, P.; Balboa, E.; Zanlungo, S.; Fabrías, G.; Casas, J.; Enrich, C.; Garcia-Ruiz, C.; Fernández-Checa, J. C. Mitochondrial GSH Replenishment as a Potential Therapeutic Approach for Niemann Pick Type C Disease. Redox Biol. 2017, 11, 60–72.
Casasampere, M.; Ordóñez, Y. F.; Casas, J.; Fabrias, G. Dihydroceramide Desaturase Inhibitors Induce Autophagy via Dihydroceramide-Dependent and Independent Mechanisms. Biochim. Biophys. Acta – Gen. Subj. 2017, 1861 (2), 264–275.
2016
Hernández-Tiedra, S.; Fabriàs, G.; Dávila, D.; Salanueva, Í. J.; Casas, J.; Montes, L. R.; Antón, Z.; García-Taboada, E.; Salazar, M.; Lorente, M.; Nylandsted, J.; Armstrong, J.; López-Valero, I.; McKee, C. S.; Serrano-Puebla, A.; García-López, R.; González- Martínez, J.; Abad, J. L.; Hanada, K.; Boya, P.; Goñi, F. M.; Guzmán, M.; Lovat, P.; Jäättelä, M.; Alonso, A.; Velasco, G. Dihydroceramide Accumulation Mediates Aytotoxic Autophagy of Cancer Cells via Autolysosome Destabilization. Autophagy 2016, 12(11), 2213-2229.
Sanllehí, P.; Abad, J.-L.; Casas, J.; Bujons, J.; Delgado, A. Bacterial versus Human Sphingosine-1-Phosphate Lyase (S1PL) in the Design of Potential S1PL Inhibitors. Bioorg. Med. Chem. 2016, 24 (18), 4381–4389.
Malik, A.; Jordao, R.; Campos, B.; Casas, J.; Barata, C.; Tauler, R. Exploring the Disruptive Effects of TBT on Lipid Homeostasis of Daphnia Magna Using Chemometric Methods. Chemom. Intell. Lab. Syst. 2016, 159, 58–68.
Sanllehí, P.; Abad, J.-L.; Bujons, J.; Casas, J.; Delgado, A. Studies on the Inhibition of Sphingosine-1-Phosphate Lyase by Stabilized Reaction Intermediates and Stereodefined Azido Phosphates. Eur. J. Med. Chem. 2016, 123, 905–915.
Reforgiato, M. R.; Milano, G.; Fabriàs, G.; Casas, J.; Gasco, P.; Paroni, R.; Samaja, M.; Ghidoni, R.; Caretti, A.; Signorelli, P. Inhibition of Ceramide de Novo Synthesis as a Postischemic Strategy to Reduce Myocardial Reperfusion Injury. Basic Res. Cardiol. 2016, 111 (2), 12, doi:10.1007/s00395-016-0533-x
Casasampere, M.; Ordoñez, Y. F.; Pou, A.; Casas, J. Inhibitors of Dihydroceramide Desaturase 1: Therapeutic Agents and Pharmacological Tools to Decipher the Role of Dihydroceramides in Cell Biology. Chem. Phys. Lipids 2016, 197, 33–44.
Phillips-Farfán, B.; Carvajal, K.; Medina-Torres, E.-A.; Espinosa-Padilla, S.-E.; Fabriàs, G.; Camacho, L. Sphingolipids as Mediators in the Crosstalk between Microbiota and Intestinal Cells: Implications for Inflammatory Bowel Disease. Mediators Inflamm. 2016, 2016, 1–11.
Laigre, E.; Hazelard, D.; Casas, J.; Serra-Vinardell, J.; Michelakakis, H.; Mavridou, I.; Aerts, J. F. G.; Delgado, A.; Compain, P. Investigation of Original Multivalent Iminosugars as Pharmacological Chaperones for the Treatment of Gaucher Disease. Carbohydr. Res. 2016, 429, 98–104.
Klionsky, D. J.; et al. Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd Edition). Autophagy. 2016;12(1):1-222.
Ordoñez, Y. F.; Gonzalez, J.; Abad, J. L.; Bedia, C.; Casas, J.; Delgado, A.; Fabrias, G. 3-Ketosphinganine Provokes the Accumulation of Dihydroshingolipids and Induces Autophagy in Cancer Cells. Mol. BioSyst. 2016, 12, 1166–1173.
Nieves, I.; Abad, J.-L.; Montes, L. R.; Goñi, F. M.; Delgado, A. Approaches to Polyunsaturated Sphingolipids: New Conformationally Restrained Analogs with Minimal Structural Modifications. Tetrahedron 2016, 72 (5), 605–612.
Delgado, A.; Martínez-Cartró, M. Therapeutic Potential of the Modulation of Sphingosine-1-Phosphate Receptors. Curr. Med. Chem. 2016, 23 (3), 242–264.
Sanllehí, P.; Abad, J. L.; Casas, J.; Delgado, A. Inhibitors of Sphingosine-1-Phosphate Metabolism (Sphingosine Kinases and Sphingosine-1-Phosphate Lyase). Chem. Phys. Lipids 2016, 197, 69–81.
Cingolani, F.; Futerman, A. H.; Casas, J. Ceramide Synthases in Biomedical Research. Chem. Phys. Lipids 2016, 197, 25–32.
2015
Casasampere, M.; Camacho, L.; Cingolani, F.; Casas, J.; Egido-Gabás, M.; Abad, J. L.; Bedia, C.; Xu, R.; Wang, K.; Canals, D.; Hannun, Y. a.; Mao, C.; Fabrias, G. Activity of Neutral and Alkaline Ceramidases on Fluorogenic N -Acylated Coumarin-Containing Aminodiols. J. Lipid Res. 2015, 56 (10), 2019–2028.
Garrido, M.; Abad, J. L.; Fabrias, G.; Casas, J.; Delgado, A. Azide-Tagged Sphingolipids: New Tools for Metabolic Flux Analysis. ChemBioChem 2015, 16 (4), 641–650.
Kiefer, K.; Carreras-Sureda, A.; García-López, R.; Rubio-Moscardó, F.; Casas, J.; Fabriàs, G.; Vicente, R. Coordinated Regulation of the Orosomucoid-like Gene Family Expression Controls de Novo Ceramide Synthesis in Mammalian Cells. J. Biol. Chem. 2015, 290 (5), 2822–2830.
Nieves, I.; Sanllehí, P.; Abad, J.-L. L.; Fabriàs, G.; Casas, J.; Delgado, A. Chemical Probes of Sphingolipid Metabolizing Enzymes. In Bioactive Sphingolipids in Cancer Biology and Therapy; Hannun, Y., Luberto, C., Obeid, L., Mao, C., Eds.; Springer International Publishing: Cham, 2015; pp 437–469.
Abad, J.-L.; Armero, I.; Delgado, A. A Straightforward Synthesis of the CERT Inhibitor (1′R,3′S)-HPA-12. Tetrahedron Lett. 2015, 56 (13), 1706–1708.
Nieves, I.; Artetxe, I.; Abad, J. L.; Alonso, A.; Busto, J. V; Fajari, L.; Montes, L. R.; Sot, J.; Delgado, A.; Goni, F. M. Fluorescent Polyene Ceramide Analogues as Membrane Probes. Langmuir 2015, 31, 2484–2492.
2014
Serra-Vinardell, J.; Díaz, L.; Guitiérrez-de Terán, H.; Sánchez-Ollé, G.; Bujons, J.; Michelakakis, H.; Mavridou, I.; Aerts, J. M. F. G.; Delgado, A.; Grinberg, D.; Vilageliu, L.; Casas, J. Selective Chaperone Effect of Aminocyclitol Derivatives on G202R and Other Mutant Glucocerebrosidases Causing Gaucher Disease. Int. J. Biochem. Cell Biol. 2014, 54, 245–254.
Jones, E. E.; Dworski, S.; Canals, D.; Casas, J.; Fabrias, G.; Schoenling, D.; Levade, T.; Denlinger, C.; Hannun, Y. A.; Medin, J. A.; Drake, R. R. On-Tissue Localization of Ceramides and Other Sphingolipids by MALDI Mass Spectrometry Imaging. Anal. Chem. (Washington, DC, United States) 2014, 86 (16), 8303–8311.
Cingolani, F.; Casasampere, M.; Sanllehí, P.; Casas, J.; Bujons, J.; Fabrias, G. Inhibition of Dihydroceramide Desaturase Activity by the Sphingosine Kinase Inhibitor SKI II. J. Lipid Res. 2014, 55 (8), 1711–1720.
Zizioli, D.; Guarienti, M.; Tobia, C.; Gariano, G.; Borsani, G.; Bresciani, R.; Ronca, R.; Giacopuzzi, E.; Preti, A.; Gaudenzi, G.; Belleri, M.; Di Salle, E.; Fabrias, G.; Casas, J.; Ribatti, D.; Monti, E.; Presta, M. Molecular Cloning and Knockdown of Galactocerebrosidase in Zebrafish: New Insights into the Pathogenesis of Krabbe’s Disease. Biochim. Biophys. Acta 2014, 1–11.
Caretti, A.; Bragonzi, A.; Facchini, M.; De Fino, I.; Riva, C.; Gasco, P.; Musicanti, C.; Casas, J.; Fabrias, G.; Ghidoni, R.; Signorelli, P. Anti-Inflammatory Action of Lipid Nanocarrier-Delivered Myriocin: Therapeutic Potential in Cystic Fibrosis. Biochim. Biophys. Acta, Gen. Subj. 2014, 1840 (1), 586–594.
Serra-Vinardell, J.; Díaz, L.; Casas, J.; Grinberg, D.; Vilageliu, L.; Michelakakis, H.; Mavridou, I.; Aerts, J. M. F. G.; Decroocq, C.; Compain, P.; Delgado, A. Glucocerebrosidase Enhancers for Selected Gaucher Disease Genotypes by Modification of α-1-C-Substituted Imino-D-Xylitols (DIXs) by Click Chemistry. ChemMedChem 2014, 9, 1744–1754.
Crehuet, R.; Mormeneo, D.; Anglada, J. M.; Delgado, A. Mechanistic Studies on the Intramolecular Cyclization of O-Tosyl Phytosphingosines to Jaspines. Nat. Prod. Commun. 2014, 9 (8), 1087–1090.
