2020
Coll-Martínez, B.; Delgado, A.; Crosas, B. The Potential of Proteolytic Chimeras as Pharmacological Tools and Therapeutic Agents. Molecules 2020, 25 (24), 5956
Casasampere, M.; Izquierdo, E.; Casas, J.; Abad, J. L.; Liu, X.; Xu, R.; Mao, C.; Chang, Y.-T.; Delgado, A.; Fabrias, G. Click and Count: Specific Detection of Acid Ceramidase Activity in Live Cells. Chem. Sci. 2020, 11, 13044–13051
Maharaj, A.; Williams, J.; Bradshaw, T.; Güran, T.; Braslavsky, D.; Casas, J.; Chan, L. F.; Metherell, L. A.; Prasad, R. Sphingosine-1-Phosphate Lyase (SGPL1) Deficiency Is Associated with Mitochondrial Dysfunction. J. Steroid Biochem. Mol. Biol. 2020, 202 (November 2019), 105730
Pearson, J. M.; Tan, S.-F.; Sharma, A.; Annageldiyev, C.; Fox, T. E.; Abad, J. L.; Fabrias, G.; Desai, D.; Amin, S.; Wang, H.-G.; et al. Ceramide Analogue SACLAC Modulates Sphingolipid Levels and MCL-1 Splicing to Induce Apoptosis in Acute Myeloid Leukemia. Mol. Cancer Res. 2020, 18 (3), 352–363.
Muñoz-Guardiola, P.; Casas, J.; Megías-Roda, E.; Solé, S.; Perez-Montoyo, H.; Yeste-Velasco, M.; Erazo, T.; Diéguez-Martínez, N.; Espinosa-Gil, S.; Muñoz-Pinedo, C.; et al. The Anti-Cancer Drug ABTL0812 Induces ER Stress-Mediated Cytotoxic Autophagy by Increasing Dihydroceramide Levels in Cancer Cells. Autophagy 2020, 15548627.2020.1761651.
Pons, G.; Riba, D.; Casasampere, M.; Izquierdo, E.; Abad, J.-L.; Fabriàs, G.; Rodríguez Ortega, P. G.; López-González, J. J.; Montejo, M.; Casas, J.; et al. A Mechanism-Based Sphingosine-1-Phosphate Lyase Inhibitor. J. Org. Chem. 2020, 85 (2), 419–429.
Randez-Gil, F.; Prieto, J. A.; Rodríguez-Puchades, A.; Casas, J.; Sentandreu, V.; Estruch, F. Myriocin-Induced Adaptive Laboratory Evolution of an Industrial Strain of Saccharomyces Cerevisiae Reveals Its Potential to Remodel Lipid Composition and Heat Tolerance. Microb. Biotechnol. 2020.
Meglič, A.; Ilić, M.; Quero, C.; Arikawa, K.; Belušič, G. Two Chiral Types of Randomly Rotated Ommatidia Are Distributed across the Retina of the Flathead Oak Borer Coraebus Undatus (Coleoptera: Buprestidae). J. Exp. Biol. 2020, 223 (14), jeb225920
2019
Casasampere, M.; Bielsa, N.; Riba, D.; Bassas, L.; Xu, R.; Mao, C.; Fabrias, G.; Abad, J.-L.; Delgado, A.; Casas, J. New Fluorogenic Probes for Neutral and Alkaline Ceramidases. J. Lipid Res. 2019, jlr.D092759.
Domínguez, A.; López, S.; Bernabé, A.; Guerrero, Á.; Quero, C. Influence of Age, Host Plant and Mating Status in Pheromone Production and New Insights on Perception Plasticity in Tuta Absoluta. Insects 2019, 10 (8), 256.
Guerrero, A.; Ramos, V. E.; López, S.; Alvarez, J. M.; Domínguez, A.; Coca-Abia, M. M.; Bosch, M. P.; Quero, C. Enantioselective Synthesis and Activity of All Diastereoisomers of ( E )-Phytal, a Pheromone Component of the Moroccan Locust, Dociostaurus Maroccanus. J. Agric. Food Chem. 2019, 67 (1), 72–80.
Solé, M.; Monge, M.; André, M.; Quero, C. A Proteomic Analysis of the Statocyst Endolymph in Common Cuttlefish (Sepia Officinalis): An Assessment of Acoustic Trauma after Exposure to Sound. Sci. Rep. 2019, 9 (1), 9340.
Ordóñez, Y. F.; Abad, J. L.; Aseeri, M.; Casas, J.; Garcia, V.; Casasampere, M.; Schuchman, E. H.; Levade, T.; Delgado, A.; Triola, G.; et al. Activity-Based Imaging of Acid Ceramidase in Living Cells. J. Am. Chem. Soc. 2019, 141 (19), 7736–7742.
Benson, S.; Fernandez, A.; Barth, N. D.; de Moliner, F.; Horrocks, M. H.; Herrington, C. S.; Abad, J. L.; Delgado, A.; Kelly, L.; Chang, Z.; et al. SCOTfluors: Small, Conjugatable, Orthogonal, and Tunable Fluorophores for In Vivo Imaging of Cell Metabolism. Angew. Chem. Int. Ed. 2019, 58 (21), 6911–6915.
Samaranch, L.; Pérez-Cañamás, A.; Soto-Huelin, B.; Sudhakar, V.; Jurado-Arjona, J.; Hadaczek, P.; Ávila, J.; Bringas, J. R.; Casas, J.; Chen, H.; et al. Adeno-Associated Viral Vector Serotype 9–Based Gene Therapy for Niemann-Pick Disease Type A. Sci. Transl. Med. 2019, 11 (506), eaat3738.
Meneses-Salas, E.; García-Melero, A.; Kanerva, K.; Blanco-Muñoz, P.; Morales-Paytuvi, F.; Bonjoch, J.; Casas, J.; Egert, A.; Beevi, S. S.; Jose, J.; et al. Annexin A6 Modulates TBC1D15/Rab7/StARD3 Axis to Control Endosomal Cholesterol Export in NPC1 Cells. Cell. Mol. Life Sci. 2019, https://doi.org/10.1007/s00018-019-03330-y.
2018
Schulte-Zweckel, J.; Schneidewind, T.; Abad, J. L.; Brockmeyer, A.; Janning, P.; Triola, G. Azide-Tagged Sphingolipids for the Proteome-Wide Identification of C16-Ceramide-Binding Proteins. Chem. Commun. 2018, 54 (97), 13742–13745.
Fanani, M. L.; Busto, J. V.; Sot, J.; Abad, J. L.; Fabrias, G.; Saiz, L.; Vilar, J. M. G.; Goni, F. M.; Maggio, B.; Alonso, A. Clearly Detectable, Kinetically Restricted Solid-Solid Phase Transition in Cis-Ceramide Monolayers. Langmuir 2018, 34 (39), 11749–11758.
Faria, M.; Fuertes, I.; Prats, E.; Abad, J. L.; Padrós, F.; Gomez-Canela, C.; Casas, J.; Estevez, J.; Vilanova, E.; Piña, B.; et al. Analysis of the Neurotoxic Effects of Neuropathic Organophosphorus Compounds in Adult Zebrafish. Sci. Rep. 2018, 8 (1), 4844.
Izquierdo, E.; Delgado, A. Click Chemistry in Sphingolipid Research. Chem. Phys. Lipids 2018, 215, 71–83.
Ordóñez-Gutiérrez, L.; Benito-Cuesta, I.; Abad, J. L.; Casas, J.; Fábrias, G.; Wandosell, F. Dihydroceramide Desaturase 1 Inhibitors Reduce Amyloid-β Levels in Primary Neurons from an Alzheimer’s Disease Transgenic Model. Pharm. Res. 2018, 35 (3), 49.
2017
Cingolani, F.; Simbari, F.; Abad, J. L.; Casasampere, M.; Fabrias, G.; Futerman, A. H.; Casas, J. J. Lipid Res. 2017, 58, 1500–1513.
Stauffert, F.; Serra-Vinardell, J.; Gómez-Grau, M.; Michelakakis, H.; Mavridou, I.; Grinberg, D.; Vilageliu, L.; Casas, J.; Bodlenner, A.; Delgado, A.; Compain, P. Stereodivergent Synthesis of Right- and Left-Handed Iminoxylitol Heterodimers and Monomers. Study of Their Impact on Beta-Glucocerebrosidase Activity. Org. Biomol. Chem. 2017, 15 (17), 3681–3705.
Sanllehí, P.; Casasampere, M.; Abad, J.-L.; Fabriàs, G.; López, O.; Bujons, J.; Casas, J.; Delgado, A. The First Fluorogenic Sensor for Sphingosine-1-Phosphate Lyase Activity in Intact Cells. Chem. Commun. 2017, 53 (39), 5441–5444.
Calderón, R.; Mercadal, N.; Abad, J.-L.; Ariza, X.; Delgado, A.; García, J.; Rodríguez, A.; Fabriàs, G. Stereoselective Preparation of Quaternary 2-Vinyl Sphingosines and Ceramides and Their Effect on the Basal Sphingolipid Metabolism. Chem Phys Lipids 2017, 205, 34–41
Gómez-Grau, M.; Albaigès, J.; Casas, J.; Auladell, C.; Dierssen, M.; Vilageliu, L.; Grinberg, D. New Murine Niemann-Pick Type C Models Bearing a Pseudoexon-Generating Mutation Recapitulate the Main Neurobehavioural and Molecular Features of the Disease. Sci. Rep. 2017, 7, 41931.
Sikora, J.; Dworski, S.; Jones, E. E.; Kamani, M. A.; Micsenyi, M. C.; Sawada, T.; Le Faouder, P.; Bertrand-Michel, J.; Dupuy, A.; Dunn, C. K.; Xuan, I. C. Y.; Casas, J.; Fabrias, G.; Hampson, D. R.; Levade, T.; Drake, R. R.; Medin, J. A.; Walkley, S. U. Acid Ceramidase Deficiency in Mice Results in a Broad Range of Central Nervous System Abnormalities. Am. J. Pathol. 2017, 187 (4), 864–883.
Pou, A.; Abad, J.-L.; Ordóñez, Y. F.; Garrido, M.; Casas, J.; Fabriàs, G.; Delgado, A. From the Configurational Preference of Dihydroceramide Desaturase-1 towards Δ6-Unsaturated Substrates to the Discovery of a New Inhibitor. Chem. Commun. 2017, 53 (31), 4394–4397.
Torres, S.; Matías, N.; Baulies, A.; Nuñez, S.; Alarcon-Vila, C.; Martinez, L.; Nuño, N.; Fernandez, A.; Caballeria, J.; Levade, T.; Gonzalez-Franquesa, A.; Garcia-Rovés, P.; Balboa, E.; Zanlungo, S.; Fabrías, G.; Casas, J.; Enrich, C.; Garcia-Ruiz, C.; Fernández-Checa, J. C. Mitochondrial GSH Replenishment as a Potential Therapeutic Approach for Niemann Pick Type C Disease. Redox Biol. 2017, 11, 60–72.
Casasampere, M.; Ordóñez, Y. F.; Casas, J.; Fabrias, G. Dihydroceramide Desaturase Inhibitors Induce Autophagy via Dihydroceramide-Dependent and Independent Mechanisms. Biochim. Biophys. Acta – Gen. Subj. 2017, 1861 (2), 264–275.
2016
Hernández-Tiedra, S.; Fabriàs, G.; Dávila, D.; Salanueva, Í. J.; Casas, J.; Montes, L. R.; Antón, Z.; García-Taboada, E.; Salazar, M.; Lorente, M.; Nylandsted, J.; Armstrong, J.; López-Valero, I.; McKee, C. S.; Serrano-Puebla, A.; García-López, R.; González- Martínez, J.; Abad, J. L.; Hanada, K.; Boya, P.; Goñi, F. M.; Guzmán, M.; Lovat, P.; Jäättelä, M.; Alonso, A.; Velasco, G. Dihydroceramide Accumulation Mediates Aytotoxic Autophagy of Cancer Cells via Autolysosome Destabilization. Autophagy 2016, 12(11), 2213-2229.
Sanllehí, P.; Abad, J.-L.; Casas, J.; Bujons, J.; Delgado, A. Bacterial versus Human Sphingosine-1-Phosphate Lyase (S1PL) in the Design of Potential S1PL Inhibitors. Bioorg. Med. Chem. 2016, 24 (18), 4381–4389.
Malik, A.; Jordao, R.; Campos, B.; Casas, J.; Barata, C.; Tauler, R. Exploring the Disruptive Effects of TBT on Lipid Homeostasis of Daphnia Magna Using Chemometric Methods. Chemom. Intell. Lab. Syst. 2016, 159, 58–68.
Sanllehí, P.; Abad, J.-L.; Bujons, J.; Casas, J.; Delgado, A. Studies on the Inhibition of Sphingosine-1-Phosphate Lyase by Stabilized Reaction Intermediates and Stereodefined Azido Phosphates. Eur. J. Med. Chem. 2016, 123, 905–915.
Reforgiato, M. R.; Milano, G.; Fabriàs, G.; Casas, J.; Gasco, P.; Paroni, R.; Samaja, M.; Ghidoni, R.; Caretti, A.; Signorelli, P. Inhibition of Ceramide de Novo Synthesis as a Postischemic Strategy to Reduce Myocardial Reperfusion Injury. Basic Res. Cardiol. 2016, 111 (2), 12, doi:10.1007/s00395-016-0533-x
Casasampere, M.; Ordoñez, Y. F.; Pou, A.; Casas, J. Inhibitors of Dihydroceramide Desaturase 1: Therapeutic Agents and Pharmacological Tools to Decipher the Role of Dihydroceramides in Cell Biology. Chem. Phys. Lipids 2016, 197, 33–44.
Phillips-Farfán, B.; Carvajal, K.; Medina-Torres, E.-A.; Espinosa-Padilla, S.-E.; Fabriàs, G.; Camacho, L. Sphingolipids as Mediators in the Crosstalk between Microbiota and Intestinal Cells: Implications for Inflammatory Bowel Disease. Mediators Inflamm. 2016, 2016, 1–11.
Laigre, E.; Hazelard, D.; Casas, J.; Serra-Vinardell, J.; Michelakakis, H.; Mavridou, I.; Aerts, J. F. G.; Delgado, A.; Compain, P. Investigation of Original Multivalent Iminosugars as Pharmacological Chaperones for the Treatment of Gaucher Disease. Carbohydr. Res. 2016, 429, 98–104.
Klionsky, D. J.; et al. Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd Edition). Autophagy. 2016;12(1):1-222.
Ordoñez, Y. F.; Gonzalez, J.; Abad, J. L.; Bedia, C.; Casas, J.; Delgado, A.; Fabrias, G. 3-Ketosphinganine Provokes the Accumulation of Dihydroshingolipids and Induces Autophagy in Cancer Cells. Mol. BioSyst. 2016, 12, 1166–1173.
Nieves, I.; Abad, J.-L.; Montes, L. R.; Goñi, F. M.; Delgado, A. Approaches to Polyunsaturated Sphingolipids: New Conformationally Restrained Analogs with Minimal Structural Modifications. Tetrahedron 2016, 72 (5), 605–612.
Delgado, A.; Martínez-Cartró, M. Therapeutic Potential of the Modulation of Sphingosine-1-Phosphate Receptors. Curr. Med. Chem. 2016, 23 (3), 242–264.
Sanllehí, P.; Abad, J. L.; Casas, J.; Delgado, A. Inhibitors of Sphingosine-1-Phosphate Metabolism (Sphingosine Kinases and Sphingosine-1-Phosphate Lyase). Chem. Phys. Lipids 2016, 197, 69–81.
Cingolani, F.; Futerman, A. H.; Casas, J. Ceramide Synthases in Biomedical Research. Chem. Phys. Lipids 2016, 197, 25–32.
2015
Casasampere, M.; Camacho, L.; Cingolani, F.; Casas, J.; Egido-Gabás, M.; Abad, J. L.; Bedia, C.; Xu, R.; Wang, K.; Canals, D.; Hannun, Y. a.; Mao, C.; Fabrias, G. Activity of Neutral and Alkaline Ceramidases on Fluorogenic N -Acylated Coumarin-Containing Aminodiols. J. Lipid Res. 2015, 56 (10), 2019–2028.
Garrido, M.; Abad, J. L.; Fabrias, G.; Casas, J.; Delgado, A. Azide-Tagged Sphingolipids: New Tools for Metabolic Flux Analysis. ChemBioChem 2015, 16 (4), 641–650.
Kiefer, K.; Carreras-Sureda, A.; García-López, R.; Rubio-Moscardó, F.; Casas, J.; Fabriàs, G.; Vicente, R. Coordinated Regulation of the Orosomucoid-like Gene Family Expression Controls de Novo Ceramide Synthesis in Mammalian Cells. J. Biol. Chem. 2015, 290 (5), 2822–2830.
Nieves, I.; Sanllehí, P.; Abad, J.-L. L.; Fabriàs, G.; Casas, J.; Delgado, A. Chemical Probes of Sphingolipid Metabolizing Enzymes. In Bioactive Sphingolipids in Cancer Biology and Therapy; Hannun, Y., Luberto, C., Obeid, L., Mao, C., Eds.; Springer International Publishing: Cham, 2015; pp 437–469.
Abad, J.-L.; Armero, I.; Delgado, A. A Straightforward Synthesis of the CERT Inhibitor (1′R,3′S)-HPA-12. Tetrahedron Lett. 2015, 56 (13), 1706–1708.
Nieves, I.; Artetxe, I.; Abad, J. L.; Alonso, A.; Busto, J. V; Fajari, L.; Montes, L. R.; Sot, J.; Delgado, A.; Goni, F. M. Fluorescent Polyene Ceramide Analogues as Membrane Probes. Langmuir 2015, 31, 2484–2492.
2014
Serra-Vinardell, J.; Díaz, L.; Guitiérrez-de Terán, H.; Sánchez-Ollé, G.; Bujons, J.; Michelakakis, H.; Mavridou, I.; Aerts, J. M. F. G.; Delgado, A.; Grinberg, D.; Vilageliu, L.; Casas, J. Selective Chaperone Effect of Aminocyclitol Derivatives on G202R and Other Mutant Glucocerebrosidases Causing Gaucher Disease. Int. J. Biochem. Cell Biol. 2014, 54, 245–254.
Jones, E. E.; Dworski, S.; Canals, D.; Casas, J.; Fabrias, G.; Schoenling, D.; Levade, T.; Denlinger, C.; Hannun, Y. A.; Medin, J. A.; Drake, R. R. On-Tissue Localization of Ceramides and Other Sphingolipids by MALDI Mass Spectrometry Imaging. Anal. Chem. (Washington, DC, United States) 2014, 86 (16), 8303–8311.
Cingolani, F.; Casasampere, M.; Sanllehí, P.; Casas, J.; Bujons, J.; Fabrias, G. Inhibition of Dihydroceramide Desaturase Activity by the Sphingosine Kinase Inhibitor SKI II. J. Lipid Res. 2014, 55 (8), 1711–1720.
Zizioli, D.; Guarienti, M.; Tobia, C.; Gariano, G.; Borsani, G.; Bresciani, R.; Ronca, R.; Giacopuzzi, E.; Preti, A.; Gaudenzi, G.; Belleri, M.; Di Salle, E.; Fabrias, G.; Casas, J.; Ribatti, D.; Monti, E.; Presta, M. Molecular Cloning and Knockdown of Galactocerebrosidase in Zebrafish: New Insights into the Pathogenesis of Krabbe’s Disease. Biochim. Biophys. Acta 2014, 1–11.
Caretti, A.; Bragonzi, A.; Facchini, M.; De Fino, I.; Riva, C.; Gasco, P.; Musicanti, C.; Casas, J.; Fabrias, G.; Ghidoni, R.; Signorelli, P. Anti-Inflammatory Action of Lipid Nanocarrier-Delivered Myriocin: Therapeutic Potential in Cystic Fibrosis. Biochim. Biophys. Acta, Gen. Subj. 2014, 1840 (1), 586–594.
Serra-Vinardell, J.; Díaz, L.; Casas, J.; Grinberg, D.; Vilageliu, L.; Michelakakis, H.; Mavridou, I.; Aerts, J. M. F. G.; Decroocq, C.; Compain, P.; Delgado, A. Glucocerebrosidase Enhancers for Selected Gaucher Disease Genotypes by Modification of α-1-C-Substituted Imino-D-Xylitols (DIXs) by Click Chemistry. ChemMedChem 2014, 9, 1744–1754.
Crehuet, R.; Mormeneo, D.; Anglada, J. M.; Delgado, A. Mechanistic Studies on the Intramolecular Cyclization of O-Tosyl Phytosphingosines to Jaspines. Nat. Prod. Commun. 2014, 9 (8), 1087–1090.
