RUBAM

Collaborations

RUBAM keeps active collaborations in biomedical research projects with pharmaceutical companies, hospitals or academia. An important part of our research is carried out together with national and international leading groups in the field of Cell Biology, Molecular Biology and Molecular Medicine. Most of these grous belong to the International Sphingolipid Club Network.

Cancer

  • T. Levade, Laboratoire de Biochimie “Maladies Metaboliques”, INSERM U.858, Institut de Médecine Moléculaire de Rangueil, Centre Hospitalier Universitaire Rangueil, Toulouse, France.
  • R. Ghidoni and P. Signorelli, Laboratory of Biochemistry and Molecular Biology, San Paolo Medical School, Milan, Italy.
  • M. Cabot, East Carolina University. Brody School of Medicine.
  • Mark Kester and Thomas Loughran: University of Virginia School of Medicine.
  • Guillermo Velasco. Departamento de Bioquimica y Biologia Molecular I, Universidad Complutense de Madrid.
  • José Lizcano, Departament Biochemistry, Institut Neurociences, Universitat Autònoma de Barcelona (SPAIN).
  • José Carlos Fernández-Checa y Carmen García Ruíz: Instituto de Investigaciones Biomédicas de Barcelona (IIBB-CSIC).
  • Chungui Mao, Daniel Canals and Yusuf Hannun: Stony Brook University School of Medicine and Stony brook Cancer Center, New York.
  • Santos Mañes, Department of Immunology and Oncology, Centro Nacional de Biotecnología (CSIC), Cantoblanco, Madrid, Spain.

Sphingolipid metabolism

  • P. P. Van Veldhoven, Laboratory of Lipid Biochemistry and Protein Interactions, Department of Molecular Cell Biology, KU Leuven, Leuven, Belgium.
  • A. Gómez-Muñoz, Departamento de Bioquímica y Biología Molecular; Universidad del País Vasco, Bilbao.
  • P. P. Van Veldhoven, Laboratory of Lipid Biochemistry and Protein Interactions, Department of Molecular Cell Biology, KU Leuven, Leuven, Belgium.

Chemometric methods

  • R.Tauler, Department of Environmental Chemistry, IDAEA-CSIC, Barcelona, Spain.

Rare Diseases

  • L. Vilageliu and D. Grinberg, Department of Genetics. Faculty of Biology. Universitat de Barcelona.
  • T. Levade, Laboratoire de Biochimie “Maladies Metaboliques”, INSERM U.858, Institut de Médecine Moléculaire de Rangueil, Centre Hospitalier Universitaire Rangueil, Toulouse, France.
  • P. Compain, Laboratoire de Synthèse Organique et Molécules Bioactives (SYBIO), Université de Strasbourg, Ecole Européenne de Chimie, Polymères et Matériaux, Strasbourg, France.
  • Edward Schuchman, Department of Genetics & Genomic Sciences. Mount Sinai School of Medicine, New York, USA.
  • Jeff Medin, Medical College of Wisconsin, Milwaukee, Wisconsin.
  • Anthony H. Futerman, Weizmann Institute of Science, Israel.

Infectious diseases

  • J. Martínez Picado, IRSI-Caixa Foundation, Hospital Germans Trias i Pujol, Badalona, Spain.

Biophysical studies

  • F. M. Goñi and A. Alonso, Unidad de Biofísica (CSIC) and Departamento de Bioquímica y Biología Molecular; Universidad del País Vasco, Bilbao, Spain.

Chemical Ecology

  • Gregor Belušič, Department of Biology University of Ljubljana, Slovenia.
  • Victor Sarto, Entomologist; Institute of Environmental Sciences and Technologies (ICTA) in the Autonomous University of Barcelona (UAB).
  • Antoni Torrell, Forestal Catalana. Departament de Medi Ambient de la Generalitat de Catalunya.
  • Mikel González de Heredia, Departamento de Medicina, UNIBE- Universidad Iberoamericana, Santo Domingo, República Dominicana.
  • Mila Coca,  Centro de Investigaciones y Tecnologías Agroalimentarias (CITA), Unidad de Sanidad Vegetal (Zaragoza, Spain).
  • Neus Aletà, Senior Researcher at Institute of Agricultural-Alimentary Research and Technology. Government of Catalonia adscribed to the Department of Agriculture.
  • Sylvia Anton, Ecology and Genetics of Insects, Institut de Génétique, Environnement et Protection des Plantes, French National Research Institute for Agriculture, Food and the Environment , France.

Publications resulting from collaborations

Seras-Franzoso J, Díaz-Riascos ZV, Corchero JL, González P, García-Aranda N, Mandaña M, Riera R, Boullosa A, Mancilla S, Grayston A, Moltó-Abad M, Garcia-Fruitós E, Mendoza R, Pintos-Morell G, Rosell A, Casas J, Villaverde A, Schwartz Jr S, Abasolo I., Extracellular vesicles from recombinant cell factories improve the activity and efficacy of enzymes defective in lysosomal storage disorders. J Extracell Vesicles. 2021, 10:e12058.

Klionsky DJ, et al, Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition), Autophagy. 2021 Feb 8:1-382

Miralpeix C, Reguera C, Fosch A, Casas M, Lillo M, Navarro G, Franco R, Casas J, Alexander SPH, Casals N, Rodríguez-Rodríguez R., CPT1C negatively regulates the endocannabinoid hydrolase ABHD6 depending on the nutritional state, British J Pharmacol, 2021, 178:1507-1523.

Hurtado, E.; Núñez‐Álvarez, Y.; Muñoz, M.; Gutiérrez‐Caballero, C.; Casas, J.; Pendás, A. M.; Peinado, M. A.; Suelves, M. HDAC11 Is a Novel Regulator of Fatty Acid Oxidative Metabolism in Skeletal Muscle. FEBS J.2021, 288:902-919

Meneses-Salas E, García-Melero A, Kanerva K, Blanco-Muñoz P, Morales-Paytuvi F, Bonjoch J, Casas J, Egert A, Beevi SS, Jose J, Llorente-Cortés V, Rye KA, Heeren J, Lu A, Pol A, Tebar F, Ikonen E, Grewal T, Enrich C, Rentero C, Annexin A6 modulates TBC1D15/Rab7/StARD3 axis to control endosomal cholesterol export in NPC1 cells, Cell. & Mol. Life Sci, 2020 Jul; 77(14):2839-2857.

Ramos-Romero S, Hereu M, Atienza L, Amézqueta S, Casas J, Muñoz S, Medina I, Miralles-Pérez B, Romeu M, Torres JLThe buckwheat iminosugar D-fagomine attenuates sucrose-induced steatosis and hypertension in rats, Mol Nutr Food Res . 2020, 64 (1) e1900564
Vélez-Santamaría V, Verdura E, Macmurdo C, Planas-Serra L, Schlüter A, Casas J, Martínez JJ, Casasnovas C, Si Y, Thompson SS, Maroofian R, Pujol A. Expanding the clinical and genetic spectrum of PCYT2-related disorders. Brain. 2020 Sep 1;143(9):e76. doi: 10.1093/brain/awaa229. PMID: 32889549.
Samouillan V, Martinez de Lejarza Samper IM, Amaro AB, Vilades D, Dandurand J, Casas J, Jorge E, Calvo DG, Gallardo A, Lerma E, Ramos JMG, Carreras F, Leta R, Llorente Cortes V. Biophysical and Lipidomic Biomarkers of Cardiac Remodeling Post-Myocardial Infarction in Humans. Biomolecules. 2020 Oct 22;10(11):1471. doi: 10.3390/biom10111471.

Nieto-Garai JA, Arboleya A, Otaegi S, Chojnacki J, Casas J, Fabrias G, Contreras F-X, Kräusslich H-G, Lorizate MCholesterol in the viral membrane is the molecular switch governing HIV-1 Env clustering, Adv Sci (Weinh). 2020 Dec 21; 8(3):2003468.

González, M. A.; Prosser, S. W.; Hernández-Triana, L. M.; Alarcón-Elbal, P. M.; Goiri, F.; López, S.; Ruiz-Arrondo, I.; Hebert, P. D. N.; García-Pérez, A. L. Avian Feeding Preferences of Culex Pipiens and Culiseta Spp. Along an Urban-to-Wild Gradient in Northern Spain . Frontiers in Ecology and Evolution . 2020, p 352

Monge, M.; Fornaguera, C.; Quero, C.; Dols-Perez, A.; Calderó, G.; Grijalvo, S.; García-Celma, M. J.; Rodríguez-Abreu, C.; Solans, C. Functionalized PLGA Nanoparticles Prepared by Nano-Emulsion Templating Interact Selectively with Proteins Involved in the Transport through the Blood-Brain Barrier. Eur. J. Pharm. Biopharm. 2020, 156, 155–164

Weber, M.; Mera, P.; Casas, J.; Salvador, J.; Rodríguez, A.; Alonso, S.; Sebastián, D.; Soler‐Vázquez, M. C.; Montironi, C.; Recalde, S.; et al. Liver CPT1A Gene Therapy Reduces Diet‐induced Hepatic Steatosis in Mice and Highlights Potential Lipid Biomarkers for Human NAFLD. FASEB J. 2020, 34 (9), 11816–11837FASEB J. 2020

Martín‐Leal, A.; Blanco, R.; Casas, J.; Sáez, M. E.; Rodríguez‐Bovolenta, E.; Rojas, I.; Drechsler, C.; Real, L. M.; Fabrias, G.; Ruíz, A.; et al. CCR 5 Deficiency Impairs CD 4 + T‐cell Memory Responses and Antigenic Sensitivity through Increased Ceramide Synthesis. EMBO J. 2020, Jun 11; 39 (15) e104749.

Kao L-P, Morad SAF, Davis TS, MacDougall MR, Kassai M, Abdelmageed N, et al. Chemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergetics in resistant HL-60 cells. J Lipid Res. 2019 Jul 30;jlr.RA119000251.

Kiefer K, Casas J, García-López R, Vicente R. Ceramide imbalance and impaired TLR4-mediated autophagy in BMDM of an ORMDL3-Overexpressing mouse model. Int J Mol Sci. 2019 Mar 20;20(6):1391.

Jiménez de Oya N, Esler WP, Huard K, El-Kattan AF, Karamanlidis G, Blázquez AB, et al. Targeting host metabolism by inhibition of acetyl-Coenzyme A carboxylase reduces flavivirus infection in mouse models. Emerg Microbes Infect. 2019 Jan 19;8(1):624–36.

Miralpeix C, Fosch A, Casas J, Baena M, Herrero L, Serra D, et al. Hypothalamic endocannabinoids inversely correlate with the development of diet-induced obesity in male and female mice. J Lipid Res. 2019 Jul;60(7):1260–9.

Barbacini P, Casas J, Torretta E, Capitanio D, Maccallini G, Hirschler V, et al. Regulation of Serum Sphingolipids in Andean Children Born and Living at High Altitude (3775 m). Int J Mol Sci. 2019 Jun 11;20(11):2835.

Fuertes, I.; Jordão, R.; Casas, F.; Barata, C. Allocation of Glycerolipids and Glycerophospholipids from Adults to Eggs in Daphnia Magna: Perturbations by Compounds That Enhance Lipid Droplet Accumulation. Environ. Pollut. 2018, 242 (Pt B), 1702–1710.

Ramos-Romero, S.; Hereu, M.; Atienza, L.; Casas, J.; Taltavull, N.; Romeu, M.; Amézqueta, S.; Dasilva, G.; Medina, I.; Torres, J. L. Functional Effects of the Buckwheat Iminosugar D-Fagomine on Rats with Diet-Induced Prediabetes. Mol. Nutr. Food Res. 2018, 62 (16), 1800373.

Jimenez de Oya, N.; Blazquez, A.-B.; Casas, J.; Saiz, J.-C.; Martin Acebes, M. A. Direct Activation of Adenosine Monophosphate-Activated Protein Kinase (AMPK) by PF-06409577 Inhibits Flavivirus Infection through Modification of Host-Cell Lipid Metabolism. Antimicrob. Agents Chemother. 2018, 62 (7), AAC.00360-18.

Herrera, J. L.; Ordoñez-Gutierrez, L.; Fabrias, G.; Casas, J.; Morales, A.; Hernandez, G.; Acosta, N. G.; Rodriguez, C.; Prieto-Valiente, L.; Garcia-Segura, L. M.; et al. Ovarian Function Modulates the Effects of Long-Chain Polyunsaturated Fatty Acids on the Mouse Cerebral Cortex. Front. Cell. Neurosci. 2018, 12, 103.

de-Madaria E, Molero X, Bonjoch L, Casas J, Cárdenas-Jaén K, Montenegro A, Closa D. Oleic acid chlorohydrin, a new early biomarker for the prediction of acute pancreatitis severity in humans, Ann Intensive Care, 2018 Jan 9;8(1):1. doi: 10.1186/s13613-017-0346-6.

Mir JF, Zagmutt S, Lichtenstein MP, García-Villoria J, Weber M, Gracia A, Fabriàs G, Casas J, López M, Casals N, Ribes A, Suñol C, Herrero L, Serra D. Ghrelin Causes a Decline in GABA Release by Reducing Fatty Acid Oxidation in Cortex, Mol Neurobiol. 2018 Feb 2. doi: 10.1007/s12035-018-0921-3.

Mira E, Carmona-Rodríguez L, Pérez-Villamil B, Casas J, Fernández-Aceñero MJ, Martínez-Rey D, Martín-González P, Heras-Murillo I, Paz-Cabezas M, Tardáguila M, Oury TD, Martín-Puig S, Lacalle RA, Fabriás G, Díaz-Rubio E, Mañes S.  SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α, Nat Commun. 2018 Feb 8;9(1):575. doi: 10.1038/s41467-018-03079-1.

Ramos-Romero S, Hereu M, Atienza L, Casas J, Jáuregui O, Amézqueta S, Dasilva G, Medina I, Nogués MR, Romeu M, Torres JL. Mechanistically different effects of fat and sugar on insulin resistance, hypertension and gut microbiota in rats. Amer J Physiol,  2018 2 Jan https://doi.org/10.1152/ajpendo.00323.2017

Caretti A, Vasso M, Bonezzi FT, Gallina A, Trinchera M, Rossi A, Adami R, Casas J, Falleni M, Tosi D, Bragonzi A, Ghidoni R, Gelfi C, Signorelli P.  Myriocin treatment of CF lung infection and inflammation: complex analyses for enigmatic lipids. Naunyn Schmiedebergs Arch Pharmacol. 2017 Apr 24. doi:10.1007/s00210-017-1373-4.

Fabiani C, Zulueta A, Bonezzi F, Casas J, Ghidoni R, Signorelli P, Caretti A.  2-Acetyl-5-tetrahydroxybutyl imidazole (THI) protects 661W cells against oxidative stress.  Naunyn Schmiedebergs Arch Pharmacol. 2017 Apr 13. 390, 741–751 doi: 10.1007/s00210-017-1374-3.

Signorelli P, Avagliano L, Reforgiato MR, Toppi N, Casas J, Fabriàs G, Marconi AM, Ghidoni R, Caretti A. De novo ceramide synthesis is involved in acute inflammation during labor. Biol Chem. 2016 Jan 1;397(2):147-55. doi: 10.1515/hsz-2015-0213. PubMed PMID: 26501163.

Simbari, F.; McCaskill, J.; Coakley, G.; Millar, M.; Maizels, R. M.; Fabriás, G.; Casas, J.; Buck, A. H. Plasmalogen Enrichment in Exosomes Secreted by a Nematode Parasite versus Those Derived from Its Mouse Host: Implications for Exosome Stability and Biology. J. Extracell. Vesicles 2016, 5 (0), 30741, doi: 10.3402/jev.v5.30741

Caretti, A.; Torelli, R.; Perdoni, F.; Falleni, M.; Tosi, D.; Zulueta, A.; Casas, J.; Sanguinetti, M.; Ghidoni, R.; Borghi, E.; Signorelli, P. Inhibition of Ceramide de Novo Synthesis by Myriocin Produces the Double Effect of Reducing Pathological Inflammation and Exerting Antifungal Activity against A. Fumigatus Airways Infection. Biochim. Biophys. Acta – Gen. Subj. 2016, 1860 (6), 1089–1097, doi: 10.1016/j.bbagen.2016.02.014

Reforgiato, M. R.; Milano, G.; Fabriàs, G.; Casas, J.; Gasco, P.; Paroni, R.; Samaja, M.; Ghidoni, R.; Caretti, A.; Signorelli, P. Inhibition of Ceramide de Novo Synthesis as a Postischemic Strategy to Reduce Myocardial Reperfusion Injury. Basic Res. Cardiol. 2016, 111 (2), 12.

Remesal, A.; De Luca, D.; San Feliciano, L.; Isidoro-Garcia, M.; Minucci, A.; Pocino, K.; Casas, J.; Fabrias, G.; Capoluongo, E. D.; de la Cruz, D. L. Effect of Prenatal Steroidal Inhibition of sPLA2 in a Rat Model of Preterm Lung. Pulm. Pharmacol. Ther. 2016, 36, 31–36.

Faggi, E.; Serra-Vinardell, J.; Pandey, M. D.; Casas, J.; Fabriàs, G.; Luis, S. V.; Alfonso, I. Pseudopeptidic Fluorescent on-off pH Sensor Based on Pyrene Excimer Emission: Imaging of Acidic Cellular Organelles. Sensors Actuators B Chem. 2016, 234, 633–640.

Denli, M.; Blandon, J.C.; Salado, S.; Guynot, M.E.; Casas, J.; Pérez, J.F. Efficacy of AdiDetox in reducing the toxicity of fumonisin B1 in rats; Food Chem. Toxicol., 2015, 78, 60-63, .

Romero-Ramírez, L.; García-Álvarez, I.; Casas, J.; Barreda-Manso, M.A.; Yanguas-Casás, N.; Nieto-Sampedro, M.; Fernández-Mayoralas, A. New oleyl glycoside as anti-cancer agent that targets on neutral sphingomyelinase. Biochem. Pharmacol., 2015, 97, 158-172, .

Signorelli P, Fabiani C, Brizzolari A, Paroni R, Casas J, Fabriàs G, Rossi D, Ghidoni R, Caretti A. Natural grape extracts regulate colon cancer cells malignancy. Nutr Cancer,  2015, 67, 494-503,

Merino-Ramos T, Vázquez-Calvo Á, Casas J, Sobrino F, Saiz JC, Martín-Acebes MA. Modification of the Host Cell Lipid Metabolism Induced by Hypolipidemic Drugs Targeting the Acetyl Coenzyme A Carboxylase Impairs West Nile Virus Replication. Antimicrob Agents Chemother. 2015, 60, 307-15, .

Jordão, R.; Casas, J.; Fabrias, G.; Campos, B.; Piña, B.; Lemos, M.F.L.; Soares, A.M.V.M.; Tauler, R.; Barata, C. Obesogens beyond vertebrates: Lipid perturbation by tributyltin in the crustacean Daphnia magna, Environ. Health Perspect., 2015, 123, 813-819,

Gorrochategui, E.; Casas, J.; Porte, C.; Lacorte, S.; Tauler, R. Chemometric strategy for untargeted lipidomics: Biomarker detection and identification in stressed human placental cells
Anal. Chim. Acta, 2015, 854, 20-33, .

Martínez, L.; Torres, S.; Baulies, A.; Alarcón-Vila, C.; Elena, M.; Fabriàs, G.; Casas, J.; Caballeria, J.; Fernandez-Checa, J. C.; García-Ruiz, C. Myristic Acid Potentiates Palmitic Acid-Induced Lipotoxicity and Steatohepatitis Associated with Lipodystrophy by Sustaning de Novo Ceramide Synthesis. Oncotarget 2015, 6 (39), 41479–41496.

Signorelli P, Avagliano L, Reforgiato MR, Toppi N, Casas J, Fabriàs G, Marconi AM, Ghidoni R, Caretti A. De novo ceramide synthesis is involved in acute inflammation during labor. Biol Chem. 2015. pii: /j/bchm.just-accepted/hsz-2015-0213/hsz-2015-0213.xml.

Kiefer K, Carreras-Sureda A, García-López R, Rubio-Moscardó F, Casas J, Fabriàs G, Vicente R. Coordinated regulation of the orosomucoid-like gene family expression controls de novo ceramide synthesis in mammalian cells. J Biol Chem. 2015, 290, 2822-30.

Jones EE, Dworski S, Canals D, Casas J, Fabrias G, Schoenling D, Levade T, Denlinger C, Hannun YA, Medin JA, Drake RR. On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging. Anal Chem. 2014, 86, 8303-11.

Mera P, Mir JF, Fabriàs G, Casas J, Costa AS, Malandrino MI, Fernández-López JA, Remesar X, Gao S, Chohnan S, Rodríguez-Peña MS, Petry H, Asins G, Hegardt FG, Herrero L, Serra D. Long-term increased carnitine palmitoyltransferase 1A expression in ventromedial hypotalamus causes hyperphagia and alters the hypothalamic lipidomic profile. PLoS One. 2014 , 9, e97195.

Zizioli D, Guarienti M, Tobia C, Gariano G, Borsani G, Bresciani R, Ronca R, Giacopuzzi E, Preti A, Gaudenzi G, Belleri M, Di Salle E, Fabrias G, Casas J, Ribatti D, Monti E, Presta M. Molecular cloning and knockdown of galactocerebrosidase in zebrafish: new insights into the pathogenesis of Krabbe’s disease. Biochim Biophys Acta. 2014, 1842, 665-75.

Caretti A, Bragonzi A, Facchini M, De Fino I, Riva C, Gasco P, Musicanti C, Casas J, Fabriàs G, Ghidoni R, Signorelli P. Anti-inflammatory action of lipid nanocarrier-delivered myriocin: therapeutic potential in cystic fibrosis. Biochim Biophys Acta. 2014, 1840, 586-94.

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